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. 2015 Mar 27;172(12):3028–3042. doi: 10.1111/bph.13103

Figure 7.

Figure 7

COX-2-derived PGE2 participates in vascular remodelling. (A) Representative immunohistochemical staining of three independent experiments of COX-2, mPGES-1, TXAS and HuR expression in non-ligated and ligated carotid arteries. (B) COX-2, mPGES-1, TXAS and HuR mRNA levels and HuR immunofluorescence in aorta from untreated or AngII-treated mice. (C) TN-C mRNA levels in aorta from mice untreated or treated with AngII or AngII plus celecoxib and mPGES-1+/+ (wild type, WT) and mPGES-1−/− mice infused or not with AngII. (D,E) Representative photographs of haematoxylin and eosin stained aortic sections, media/lumen ratio and cross-sectional area (CSA) from untreated or treated with AngII or AngII plus celecoxib-treated and from WT and mPGES-1−/− mice infused or not with AngII. Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01 versus untreated; †P < 0.05, ††P < 0.01 versus AngII. n = 3–7.