Fig. 1.

Regions of WM reduction identified on full-factorial analysis among CBS patients, RS patients, and controls. Widespread patterns of WM reduction are mainly identified in the bilateral frontal and limbic subcortical WM and midbrain. The most significant areas of atrophy within the frontal and limbic lobes include the left anterior cingulate and right medial frontal gyrus. The SPM of the f statistics is displayed in a standard format as a maximum intensity projection viewed from the right-hand side (left image), the back (middle image), and the top (right image) of the brain.