Table 1.
Patient and control characteristics.
| CBS (n = 18) | RS (n = 33) | Control (n = 32) | p value | |
|---|---|---|---|---|
| Age at the time of MRI (y) | 79 ± 5 | 78 ± 6 | 79 ± 3 | 0.67 ⁎ |
| Age at symptom onset (y) | 74 ± 5 | 74 ± 5 | NA | 0.43 ⁎⁎ |
| Male/Female | 3/15 | 20/13 | 19/13 | 0.005 ⁎⁎⁎ |
| Disease duration at time of MRI (y) | 4.6 ± 2.3 (1-9) | 4.8 ± 2.6 (1-10) | NA | 0.79 ⁎⁎ |
| Neurological examination findings at the time of MRI | ||||
| Asymmetry | 18 (100%) | 4 (12%) | NA | < 0.001 ⁎⁎⁎⁎ |
| Tremor | 6 (33%) | 8 (24%) | NA | 0.49 ⁎⁎⁎⁎ |
| Rigidity | 18 (100%) | 32 (97%) | NA | 0.46 ⁎⁎⁎⁎ |
| Limb apraxia | 14 (78%) | 1 (3%) | NA | < 0.001 ⁎⁎⁎⁎ |
| Apraxia of speech | 12 (67%) | 2 (6%) | NA | < 0.001 ⁎⁎⁎⁎ |
| Alien limb | 2 (13%) a | 1 (3%) | NA | 0.19 ⁎⁎⁎⁎ |
| Myoclonus | 4 (25%) a | 0 (0%) | NA | 0.003 ⁎⁎⁎⁎ |
| vertical gaze limitation | 5 (28%) | 25 (76%) | NA | < 0.001 ⁎⁎⁎⁎ |
| Falls | 9 (64%) b | 33 (100%) | NA | < 0.001 ⁎⁎⁎⁎ |
| L-dopa benefit (subjective) | 0 (0%) | 7 (21%) | NA | 0.04 ⁎⁎⁎⁎ |
| Yahr stage | 3.8 ± 1.0 | 3.9 ± 0.9 | NA | 0.68 ⁎⁎⁎⁎⁎ |
| 1 | 0 | 1 | NA | |
| 2 | 0 | 2 | NA | |
| 2.5 | 3 | 2 | NA | |
| 3 | 2 | 6 | NA | |
| 4 | 8 | 14 | NA | |
| 5 | 5 | 8 | NA | |
Data are shown as absolute numbers or the mean ± standard deviation
Note − CBS = corticobasal syndrome, NA = not applicable, RS = Richardson’s syndrome, y = years
*
One-way ANOVA
**
The unpaired t test
***
Kruskal–Wallis test
****
Chi-square test
*****
Mann–Whitney U test
a
There were no relevant data in the medical records of two CBS patients
b
There were no relevant data in the medical records of four CBS patients