Table 2.

Effect of the aqueous extracts of the constituent plants of Nefang on Brewer’s Yeast-induced hyperpyrexia in wistar rats

Treatment (Drug/Aqueous Extract)	Dose (mg/kg)	Basal Temperature	Body temperature [BT] (°C) and pyrexia inhibition [PI] (%) over time (minutes) $\left(\overline{\mathrm{x}}\pm \mathrm{S}\mathrm{D},\mathrm{n}=4\right)$
			30		60		120		180		240
			BT	PI	BT	PI	BT	PI	BT	PI	BT	PI
Normal Saline	-	37.00 ± 0.29	37.95 ± 0.21	0.0	38.14 ± 0.38	0.0	38.65 ± 0.32	0.0	38.91 ± 0.11	0.0	38.96 ± 0.54	0
Paracetamol	150	36.90 ± 0.38	37.70 ± 0.45	15.8	37.75 ± 0.33	25.4	37.85 ± 0.28*	42.4	37.47 ± 0.26*	70.2	37.00 ± 0.39**	94.9
Mangifera indica bark	200	36.90 ± 0.31	37.85 ± 0.39	0.0	37.90 ± 0.41	12.3	37.75 ± 0.27*	48.5	37.55 ± 0.25*	66.0	37.20 ± 0.41*	84.7
	400	36.95 ± 0.92	37.95 ± 0.27	0.0	38.15 ± 0.54	0.0	37.73 ± 0.31*	52.7	37.50 ± 0.19*	71.2	37.30 ± 0.38*	82.1
Mangifera indica leaf	200	37.00 ± 0.74	37.85 ± 0.16	10.5	37.95 ± 0.37	16.7	37.60 ± 0.18*	63.6	37.35 ± 0.11*	81.7	37.20 ± 0.28*	89.8
	400	37.05 ± 0.67	38.45 ± 0.43	0.0	38.60 ± 0.29	0.0	38.25 ± 0.17*	27.3	37.90 ± 0.28*	55.5	37.50 ± 0.19*	77.0
Psidium guajava leaf	200	36.95 ± 0.51	38.00 ± 0.54	0.0	38.40 ± 0.61	0.0	38.70 ± 0.19	0.0	38.65 ± 0.38	11.0	38.50 ± 0.17	20.9
	400	37.10 ± 0.33	38.00 ± 0.15	5.3	38.65 ± 0.72	0.0	38.75 ± 0.24	0.0	38.55 ± 0.36	24.1	38.45 ± 0.11	31.1
Carica papaya leaf	200	37.00 ± 0.61	38.25 ± 0.27	0.0	38.60 ± 0.36	0.0	38.68 ± 0.22	0.0	38.65 ± 0.31	13.6	38.60 ± 0.26	18.4
	400	36.90 ± 0.68	37.90 ± 0.51	0.0	38.45 ± 0.29	0.0	38.65 ± 0.31	0.0	38.70 ± 0.29	5.8	38.60	13.3
Cymbopogon citratus leaf	200	36.95 ± 0.28	37.90 ± 0.89	0.0	37.85 ± 0.18	21.1	37.45 ± 0.35*	69.7	37.20 ± 0.52*	86.9	37.00 ± 0.09**	97.4
	400	37.00 ± 0.41	38.05 ± 0.62	0.0	37.70 ± 0.09	38.6	37.45 ± 0.18*	72.7	37.30 ± 0.56*	84.3	37.05 ± 0.22**	97.4
Citrus sinensis leaf	200	37.00 ± 0.22	38.00 ± 0.20	0.0	38.05 ± 0.25	7.9	37.85 ± 0.26*	48.5	37.55 ± 0.19*	71.2	37.35 ± 0.35*	82.1
	400	37.05 ± 0.15	38.05 ± 0.31	0.0	38.25 ± 0.18	0.0	37.75 ± 0.11*	57.6	37.45 ± 0.55*	79.1	37.25 ± 0.28*	89.8
Ocimumgratissimum leaf	200	37.00 ± 0.33	37.95 ± 0.46	0.0	37.90 ± 0.42	21.1	37.75 ± 0.19*	54.5	37.40 ± 0.38*	79.1	37.15 ± 0.52**	92.3
	400	37.00 ± 0.81	37.95 ± 0.19	0.0	38.00 ± 0.19	12.3	37.75 ± 0.09*	54.5	37.45 ± 0.61*	76.4	37.10 ± 0.33**	94.9

Significant difference * - p < 0.05, ** - p < 0.001 when compared to the control