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. 2015 Jun 8;5:10666. doi: 10.1038/srep10666

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Copyright © 2015, Macmillan Publishers Limited

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(a) Outline of the experimental setup. (b) At the time point of transplantation, human neural progenitor (hNP) spheres showed expression of HuC/D, a general marker of neurons, and Nkx6.1, a marker of ventral spinal cord progenitors but no expression of the dorsal progenitor markers Pax7 and Msx1. Scale bar, 50μm. (c) At 10 days of in vitro differentiation, hNP showed expression of HuC/D, the glial cell marker GFAP and several transcription factors indicating a spinal progenitor lineage of neuronal cells (Nkx6.1, Chx10, Islet1). (d) At 21 days of in vitro differentiation, hNP gave rise to calbindin⁺ interneurons, ChAT⁺ cholinergic neurons and inhibitory neurons indicated by the expression of VIAAT. Scale bar, 20 μm.