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. 2015 Jun 8;5:10666. doi: 10.1038/srep10666

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Copyright © 2015, Macmillan Publishers Limited

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(a) Before re-lesioning of L3-L5 dorsal roots adjacent to transplanted hNP at five months after surgery, transplanted animals showed a statistically significant improvement in ipsilateral hind paw grip strength over non-transplanted (DRA) animals. (b) Two weeks after re-lesioning, the ipsilateral grip strength was completely absent. (c+d) Re-lesoning, completely abolished the restored mechanical nociceptive function and did not lead to mechanical allodynia. * indicates significant difference compared to sham, # indicates significant difference compared to DRA. PWF, paw withdrawal frequency; PWT, paw withdrawal threshold, data shown in a-d is in mean+SEM. Asterisks indicate level of statistical significance by one-way ANOVA with Tukey’s multiple comparison (#,*p < 0.05, ##,**p < 0.01, ***p < 0.001).