Figure 5.

Histological slides of the rabbit’s calvaria bones, slice made in the coronal plane: (A) Histotopogram, including two regions of newly formed bone tissue growing toward each other; (B) the central area, where a fragment of the woven bone tissue formed on the implant surface without fibrous tissue interlayer; (C) the central area with pore in the 3D printed implant a fibrous tissue with single vascular vessels grow out through (*); (D) a fragment of the marginal part of the regenerate where newly formed bone tissue grew directly on the 3D printed block surface; (E) the marginal part of the regenerate having pronounced newly formed bone trabecule retaining the implant. 1, 3D printed block made of octacalcium phosphate; 2, newly formed bone tissue; *vascular vessel. Staining: hematoxylin and eosin, paraffin sections. Magnification: (A) ×4, (C–E) ×100, (B) ×200.