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. 2015 Jun 8;5:11149. doi: 10.1038/srep11149

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Copyright © 2015, Macmillan Publishers Limited

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(A) Chemical structure of 4-vinylphenol (4VP). (B) HPLC chromatograms of 4VP and HD aqueous extract. (C) HD aqueous extract inhibited cell proliferation, tube formation, migration and motility in HUVEC in a concentration-dependent manner. Results are expressed as the mean + SD of 3–4 independent experiments. (D) HD aqueous extract inhibited subintestinal vessel formation in zebrafish embryos. Results are expressed as the mean + SEM (n = 30–40) of 3 independent experiments. Differences between the treated and untreated control groups were determined by one-way ANOVA with Tukey’s post-hoc test. *p < 0.05, **p < 0.01, ***p < 0.005 as compared among groups.