Table 1. Effect of various doses of gentamicin on renal function in minipigs.
| (mg/kg) | CON | 5 | 6.85 | 10 | 15 | 20 | 40 | 60 | 80 | 100 |
|---|---|---|---|---|---|---|---|---|---|---|
| BUN (mmol/L) | 3.3 ± 0.8 | 4.6 ± 0.3 | 3.9 ± 0.9 | 5.3 ± 0.5 | 6.0 ± 1.6 | 5.2 ± 1.1 | 7.2 ± 2.7 | 9.1 ± 1.7 | 29.4 ± 6.4* | 83.9 ± 5.6*# |
| SCr (μmol/L) | 66.0 ± 5.0 | 90.7 ± 9.6 | 84.9 ± 2.1 | 99.4 ± 5.4 | 108.4 ± 29.1 | 92.0 ± 8.8 | 178.7 ± 52.9 | 156.7 ± 11.9 | 366.1 ± 78.9* | 1137.6 ± 348.3*# |
BUN, blood urea nitrogen; Scr, serum creatinine. Values are presented as means ± SD (n = 3). *p < 0.05 vs. CON, # p < 0.05 vs. 80 mg/kg gentamicin.