Figure 2.

Comparison of serum FI levels in advanced age-related macular degeneration (AAMD) and non-AAMD/CFI rare variant groups. Serum FI levels were measured for 209 individuals. The mean of the 79 patients with AAMD and rare genetic CFI variants was 34.8 μg/ml (95% CI: 31.8–37.8). For the 48 AAMD patients with no rare genetic CFI variants, the mean was 40.1 μg/ml (95% CI: 37.8–42.4). In those without AAMD and with genetic variants (n = 35), the mean was 44.8 μg/ml (95% CI: 41.8–47.9). In the non-AAMD without a genetic variant (n = 47) the mean was 39.2 μg/ml (95% CI: 37.2–41.2). The box plots show medians and quartiles. The means are shown as black circles. Individual patient values are shown as diamonds. Analysis of variance was undertaken by one-way ANOVA with post hoc analysis. The lower limit of normal is demonstrated by a dotted line (29.3 μg/ml) (*P = 0.03, **P < 0.001). Subjects with low serum FI levels are shown as n (%).