. 2015 Mar 18;24(13):3861–3870. doi: 10.1093/hmg/ddv091

Table 3.

Distribution of variables according to serum FI level among all subjects with a rare CFI variant

Variable	Low serum FI (n = 35)	Normal/high serum FI (n = 79)	P-value^a
Age at sample (mean ± SD)	76.6 ± 9.5	75.9 ± 8.1	0.68
Gender (n, % male)	19 (54.3)	24 (30.4)	0.02
AMD groups^b
Non-AAMD	2 (5.7)^c	33 (41.8)	5.6 × 10⁻⁵
AAMD	33 (94.3)	46 (58.2)

CFI, complement factor I (gene); FI, factor I (protein).

Variables are presented as n (%) or (mean ± SD).

^aP-values calculated as follows: one-way ANOVA for age at sample; Fisher's exact test for AMD Groups.

^bAMD classifications: non-AAMD: no AMD, early or intermediate AMD defined as subjects with CARMS grades (17), 2 or 3a in at least one eye and no advanced disease in the worst eye; AAMD, advanced AMD defined as subjects with CARMS grades 3b, 4 or 5 in at least one eye.

^cFor the two individuals in the non-AAMD group with a type 1 mutation, retinal screening at the beginning of the study revealed grade 3 maculopathy at ages 42 and 73, respectively. With additional follow-up time, the 73-year-old individual has progressed to grade 4 (advanced dry AMD).