Table 2.
Enrichment of risk SNPs at ovarian cancer susceptibility loci coinciding with regulatory biofeatures
| Cell Type | 17 HGSOC risk regions |
Genome-wide |
P-value | ||||
|---|---|---|---|---|---|---|---|
| Total number of regulatory biofeatures | Number of SNP-regulatory overlaps | Proportion of SNP-regulatory overlaps, % | Total number of regulatory biofeatures | Number of SNP-regulatory overlaps | Percentage SNP-regulatory overlaps, % | ||
| FTSEC | 676 | 159 | 23.5 | 39 706 715 | 3 547 703 | 8.9 | 3.77 × 10−30 |
| OSEC | 676 | 143 | 21.2 | 39 706 715 | 3 480 272 | 8.8 | 2.38 × 10−23 |
| EEC | 676 | 63 | 9.3 | 39 706 715 | 3 681 106 | 9.3 | 0.449 |
| HMEC | 676 | 156 | 23.1 | 39 706 715 | 4 931 084 | 12.4 | 6.71 × 10−15 |
| LNCaP | 676 | 44 | 6.5 | 39 706 715 | 3 087 796 | 7.8 | 0.878 |