Table 2.

Significant and suggestive (P < 5.0 × 10⁻⁶) SNPs from meta-analysis of 1000 Genomes-imputed data, from conditional analysis.

SNP	Chr	BP (Build 37)	A1	A2	Nearest gene	Conditioning	QIMR				ALSPAC				Meta-analysis
							Freq A1	Beta	SE	P	Freq A1	Beta	SE	P	P
Conditioning on rs1805313 only
rs10121150	9	116 131 695	A	G	BSPRY	Before	0.797	−0.122	0.036	6.57 × 10−4	0.786	−0.143	0.033	1.12 × 10−5	3.35 × 10−8
						After	0.797	−0.105	0.035	0.003	0.786	−0.133	0.032	4.48 × 10−5	5.06 × 10−7
rs8177812	9	116 151 527	A	G	ALAD	Before	0.112	0.041	0.056	0.461	0.122	−0.016	0.039	0.676	0.935
						After	0.112	0.221	0.056	6.91 × 10−5	0.122	0.131	0.046	0.005	2.27 × 10−6
Conditioning on rs10121150 and rs8177812
rs1805313	9	116 151 191	A	G	ALAD	Before	0.726	0.265	0.044	1.65 × 10−9	0.683	0.142	0.027	2.22 × 10−7	3.91 × 10−14
						After	0.726	0.274	0.044	4.13 × 10−10	0.683	0.183	0.032	1.95 × 10−8	1.63 × 10−16
rs8177800	9	116 154 099	C	T	ALAD	Before	0.918	0.611	0.087	2.76 × 10−12	0.926	0.183	0.056	9.64 × 10−4	7.17 × 10−11
						After	0.918	0.576	0.087	3.66 × 10−11	0.926	0.182	0.056	0.001	2.69 × 10−10

First, the allele count for the most significant SNP from the meta-analysis (rs1805313) was included as a covariate in association analysis, and two other SNPs (rs10121150 and rs8177812) then showed suggestive association with blood lead. Second, allele counts for rs10121150 and rs8177812 were included as covariates. A1 is the effect allele.