Table 3.
Probes at which cord blood methylation is associated with birth weight
| Probe | EWAS results |
Longitudinal analysis results |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Associated gene | Chr | Coordinates | t-statistic | P-value | FDR P-value | Average cord blood methylation (%) | Average yearly change between 0 and 7 (%) | Average yearly change between 7 and 17 (%) | Average difference in childhood yearly change, per kg increase in BWT (%) | |
| Probes with a negative association between birth weight and methylation in both the ARIES and MoBa cohorts (8) | ||||||||||
| cg20076442 | NA | 8 | 72 907 751 | −5.89 | 6.01E−09 | 2.92E−04 | 72.4 | −4.3 | −0.11 | 0.38 |
| cg25953130 | ARID5B | 10 | 63 423 556 | −5.83 | 8.23E−09 | 3.31E−04 | 55.1 | n/a | n/a | 0.60 |
| Probes with a negative association between birth weight and methylation in the ARIES cohort only | ||||||||||
| cg04521626 | PLD2 | 17 | 4 661 168 | −6.60 | 8.01E−11 | 3.89E−05 | 57.2 | −3.5 | n/a | 0.40 |
| cg14097568 | NA | 1 | 94 565 530 | −6.18 | 1.06E−09 | 1.62E−04 | 53.7 | −1.9 | −0.51 | 0.37 |
| cg17133774 | CHD5 | 1 | 6 121 254 | −6.06 | 2.17E−09 | 2.11E−04 | 30.0 | −2.8 | n/a | 0.74 |
| cg00654448 | NA | 8 | 142 434 497 | −5.93 | 4.83E−09 | 2.61E−04 | 16.5 | −0.8 | n/a | 0.38 |
| cg00442282 | RARA | 17 | 35 724 590 | −5.84 | 7.77E−09 | 3.31E−04 | 25.3 | −1.1 | −0.08 | 0.39 |
| cg13696490 | LOC201651 | 3 | 152 970 696 | −5.82 | 8.87E−09 | 3.31E−04 | 66.6 | 0.4 | −0.47 | 0.37 |
| cg12044213 | CCHCR1;TCF19 | 6 | 31 232 957 | −5.69 | 1.83E−08 | 5.54E−04 | 67.0 | −2.0 | −0.27 | 0.23 |
| cg08817867 | NA | 17 | 19 597 146 | −5.65 | 2.29E−08 | 6.16E−04 | 42.7 | −1.9 | n/a | 0.62 |
| cg00382138 | CFI;CFI | 4 | 110 942 748 | −5.64 | 2.50E−08 | 6.39E−04 | 67.6 | −1.1 | −0.17 | 0.56 |
| cg06870470 | DOCK6 | 19 | 11 176 767 | −5.58 | 3.39E−08 | 8.24E−04 | 34.3 | −3.3 | n/a | 0.29 |
| cg25557739 | NA | 14 | 96 814 038 | −5.46 | 6.73E−08 | 1.49E−03 | 41.5 | −1.2 | −0.24 | 0.09 |
| Probes with a positive association between birth weight and methylation in the ARIES cohort only | ||||||||||
| cg24324628 | NHSL1 | 6 | 138 908 575 | 6.41 | 2.62E−10 | 6.36E−05 | 80.8 | 0.9 | −0.06 | −0.28 |
| cg15783941 | NFIX | 19 | 12 993 221 | 6.14 | 1.33E−09 | 1.62E−04 | 75.4 | 1.4 | n/a | −0.35 |
| cg14597739 | LTA | 6 | 31 647 977 | 6.03 | 2.63E−09 | 2.13E−04 | 65.3 | 0.2 | 0.11 | −0.39 |
| cg22962123 | HOXA3 | 7 | 27 120 130 | 6.00 | 3.12E−09 | 2.17E−04 | 81.2 | 1.1 | n/a | −0.38 |
| cg05851442 | HOXA3 | 7 | 27 119 737 | 5.94 | 4.55E−09 | 2.61E−04 | 79.8 | 1.3 | n/a | −0.46 |
| cg23387597 | ITPRIP | 10 | 106 083 768 | 5.77 | 1.15E−08 | 3.98E−04 | 82.9 | 0.4 | 0.05 | −0.30 |
| cg24973755 | MAEA | 4 | 1 294 972 | 5.70 | 1.75E−08 | 5.54E−04 | 76.3 | 0.2 | −0.15 | −0.42 |
| cg16219283 | LTA | 6 | 31 647 981 | 5.68 | 1.94E−08 | 5.54E−04 | 68.0 | n/a | 0.13 | −0.27 |
| cg25799241 | NA | 8 | 144 877 728 | 5.46 | 6.46E−08 | 1.49E−03 | 68.2 | 1.9 | n/a | −0.32 |
| cg06658067 | NA | 16 | 29 301 844 | 5.45 | 7.05E−08 | 1.49E−03 | 73.6 | n/a | −0.04 | −0.17 |