Fig. 2.

Schematic view of the role of Btk and PI3Kδ molecules in non-malignant cells. The scheme summarizes the main cellular functions, in which Bruton tyrosine kinase (Btk) phosphoinositol 3 kinase (PI3K) δ molecules are involved in NK cells, T cells, macrophages, and osteoclasts. On the right section, some data concerning the effects of ibrutinib and idelalisib on these cells are indicated. NK natural killer, TLR toll-like receptor, CDC complement-dependent cytotoxicity, ADCC antibody-dependent cell-mediated cytotoxicity, IFNγ interferon γ, TCR T cell receptor, OC osteoclasts, MM multiple myeloma