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. Author manuscript; available in PMC: 2015 Jun 8.
Published in final edited form as: Brain. 2006 Jul 14;129(0 10):2667–2678. doi: 10.1093/brain/awl162

Fig. 3.

Fig. 3

(Top) Regions in which the metabolic effects of treatment were different for STN stimulation and levodopa infusion. Metabolic increases with stimulation relative to levodopa (left) were present in a cluster of voxels in the thalamus, extending into the subthalamic region. Relative metabolic decreases with stimulation (right) were present in the ventromedial prefrontal cortex. [SPM {t} maps were superimposed on a single-subject MRI brain template. Treatment-induced metabolic differences across interventions (blue–green scale) were thresholded at t = 2.6, P = 0.01 within the hypothesis-testing mask]. (Bottom) Bar graphs illustrating rates of glucose utilization for the significant clusters displayed above. Metabolic values (mean ± SE) are presented for each treatment condition. [OFF (filled bars) and ON (open bars) correspond to the treatment conditions for the stimulation (DBS) and levodopa (LD) groups. Regional changes with intervention appear in parentheses.]