Table 2.

Brain regions with significant metabolic changes with treatment

Brain region	Coordinatesa			Z max
	x	y	z
(A) STN DBS
Metabolic decreases (ON < OFF)
Cerebellar vermis, lobule Vb,*	10	–54	–22	–2.77
	–6	–56	–22	–2.74
Putamen**	36	18	–6	–3.48
GPi*	–16	14	–6	–2.30
Prefrontal gyrus, BA 10**	–16	60	–6	–3.41
Precentral gyrus, BA 4**	–50	–16	40	–3.39
	28	–24	52	–2.28
	36	–32	62	–2.50
Metabolic increases (ON > OFF)
Ventrolateral thalamus/STN*	–10	–14	8	–2.48
Precuneus, BA 7*	14	–74	32	–2.58
(B) Levodopa infusion
Metabolic decreases (ON < OFF)
Cerebellar vermis, lobule	6	– 46	–22	4.05
Putamen/GP/thalamus**	–34	–14	–6	3.83
Precentral gyrus, BA 4†	–16	–28	54	4.67
	14	–30	68	3.45
Metabolic increases (ON > OFF)
Cerebellar hemisphere, lobule IV*	42	–54	–26	2.68
Prefrontal gyrus, BA 10, 11*	28	58	10	2.86
Precuneus, BA 7, 31*	2	–68	26	2.87

^aMontreal Neurological Institute (MNI) standard space.

^bAccording to the atlas of Schmahmann (Schmahmann et al., 2000).

^*P < 0.01

^**P < 0.001 (uncorrected, within hypothesis-testing mask)

^†P < 0.05 (corrected for multiple non-independent comparisons).