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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Curr Opin Hematol. 2015 Jul;22(4):293–301. doi: 10.1097/MOH.0000000000000148

Fig. 2. Direct and indirect effects of pyroptosis and necroptosis on emergency hematopoiesis.

Fig. 2

The non-apoptotic and inflammatory forms of cell death, pyroptosis and necroptosis, have direct and indirect effects on emergency hematopoiesis. These modalities of cell death release inflammatory cytokines and DAMPs that stimulate emergency hematopoiesis. In chronic settings, including prolonged periods of infectious stress that may be characterized by secondary infection or systemic infection, these inflammatory factors may impair hematopoiesis. Pyroptosis and necroptosis can also exert a strong influence on hematopoiesis by directly killing HSPC.