Table 4. Log(IC50) and maximal responses for ADO- and A2A-selective agonist CGS.
| Log(IC50) | % Decrease from Basal | ||||
|---|---|---|---|---|---|
|
|
|
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| Arteriole | Venule | Maximal concentration | Arteriole | Venule | |
| ADO | −9.8±0.2*† | −8.4±0.2 | ADO 10 5 M | 44.4±2.9 | 54.0±5.4 |
| CGS | −7.5±1.1 | −8.5±0.4 | CGS 10−6 M | 45.9±4.8 | 41.0±7.7 |
Values are means ± SE. CGS, CGS21680; , permeability to rat serum albumin.
P < 0.05 vs. CGS in arteriole.
P < 0.05 vs. ADO in venule.