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. Author manuscript; available in PMC: 2016 May 21.
Published in final edited form as: Chem Biol. 2015 May 21;22(5):619–628. doi: 10.1016/j.chembiol.2015.04.013

Figure 6. Reduction of 2-AG levels attenuates peroxide-dependent CB1 signaling.

Figure 6

(A) 2-AG levels in Neuro-2a cells overexpressing MGL. (B-D) Effects of H2O2, alone or combined with CB1 antagonist rimonabant, CB2 antagonist AM630 or MGL inhibitor JZL184 (each at 1 μM), on wild-type (open bars) or MGL-overexpressing Neuro-2a cells: (B) LDH release, (C) MTT reduction, and (D) caspase-3 activity. ***P<0.001, **P<0.05 and * P<0.05 compared to Mock, and ###P<0.001 compared to MGL, two-tailed Student’s t test.