(A) 2-AG levels in Neuro-2a cells overexpressing MGL. (B-D) Effects of H2O2, alone or combined with CB1 antagonist rimonabant, CB2 antagonist AM630 or MGL inhibitor JZL184 (each at 1 μM), on wild-type (open bars) or MGL-overexpressing Neuro-2a cells: (B) LDH release, (C) MTT reduction, and (D) caspase-3 activity. ***P<0.001, **P<0.05 and * P<0.05 compared to Mock, and ###P<0.001 compared to MGL, two-tailed Student’s t test.