Table 2. Univariate and multivariate Cox proportional hazards models with LGD/HGD/EAC or HGD/EAC as the outcome.
| Univariate model variable | Group (N) |
Outcome |
|||||
|---|---|---|---|---|---|---|---|
|
Detection of LGD/HGD/EAC |
Detection of HGD/EAC |
||||||
| P value | HR | 95% CI | P value | HR | 95% CI | ||
| Inflammation No | 50 | ||||||
| Inflammation Yes | 46 | 0.0005 | 3.4 | (1.7, 7.5) | 0.003 | 5.8 | (1.6, 21.4)] |
| Aneuploidy No | 31 | ||||||
| Aneuploidy Yes | 8 | 0.007 | 4.0 | (1.4, 12.1) | 0.13 | 3.8 | (0.6, 23.7) |
| Elevated 4N No | 27 | ||||||
| Elevated 4N Yes | 12 | 0.005 | 4.4 | (1.4, 13.6) | 0.84 | 1.2 | (0.2, 7.3) |
| Elevated 4N or aneuploidy No | 24 | ||||||
| Elevated 4N or aneuploidy Yes | 15 | 0.003 | 5.7 | (1.6, 20.9) | 0.13 | 4.8 | (0.5, 43.5) |
| Age >60 No | 44 | ||||||
| Age >60 Yes | 52 | 0.58 | 0.8 | (0.4, 1.6) | 0.28 | 0.57 | (0.21, 1.6) |
| Inflammation or flow abnormality No | 16 | ||||||
| Inflammation or flow abnormality Yes | 23 | 0.003 | Infinite | NA | 0.11 | Infinite | NA |
| Inflammation or flow abnormality No* | 39 | ||||||
| Inflammation or flow abnormality Yes* | 61 | <0.0001 | 18.8 | (4.5, 79) | <0.02 | 10.3 | (1.7, 63) |
| BE length long No | 29 | ||||||
| BE length long Yes | 30 | 0.43 | 1.4 | (0.6, 3.4) | 0.19 | 2.5 | (0.6, 10.4) |
| Nodule No | 52 | ||||||
| Nodule Yes | 7 | 0.97 | 1 | (0.2, 4.2) | 0.93 | 1.1 | (0.1, 8.9) |
| Hernia No | 22 | ||||||
| Hernia Yes | 37 | 0.55 | 1.4 | (0.5, 3.7) | 0.66 | 1.4 | (0.3, 6.9) |
| Multivariate Cox model |
(N=39, 12 events) |
(N=39, 5 events) |
|||||
| Inflammation | 0.02 | 4.9 | (1.4, 17.8) | 0.04 | 15.1 | (1.1, 213) | |
| Any flow abnormality | 0.002 | 9.7 | (2.3, 40.1) | 0.06 | 11.5 | (0.8, 157) | |
BE, Barrett's esophagus; CI, confidence interval; EAC, esophageal adenocarcinoma; HGD, high-grade dysplasia; HR, hazards ratio; LGD, low-grade dysplasia; NA, not applicable
*Based on a multiple imputation (unbiased) menthod.