Table 4.

Fasting blood glucose and insulin dose

	Baseline (Visit 2)	End of period 1	End of period 2
FBG (before breakfast) in mmol/L, mean ± SD
Sequence A	9.24 ± 2.23	6.48 ± 1.66	6.27 ± 1.32
Sequence B	9.50 ± 2.16	6.60 ± 1.82	6.15 ± 1.42
p-value*		0.55	0.46
Daily insulin doses in U, mean ± SD
Sequence A	0	24.9 ± 20.3	28.7 ± 20.1
Sequence B	0	24.8 ± 15.7	26.0 ± 17.0
p-value*		0.96	0.21
Insulin doses by bodyweight in U/kg, mean ± SD
Sequence A	0	0.27 ± 0.20	0.31 ± 0.21
Sequence B	0	0.27 ± 0.15	0.28 ± 0.16
p-value*		0.88	0.13

Legend: * Unpaired t-test was applied for comparison of treatments in periods; Sequence A: starting with insulin glargine and then switching to NPH insulin; Sequence B: starting with NPH insulin and then switching to insulin glargine