Table 4.
Relationship of HSD11B1 gene polymorphic variants with obesity, the metabolic syndrome, and diabetes: studies and subjects’ characteristics
| Author, year | Subjects’ characteristics | T2DM | BMI (kg/m 2 ) | MetS | HSD11B1 polymorphisms | Association with metabolic parameters |
|---|---|---|---|---|---|---|
| Franks, 2004 [30] | n: 918 | 512 (55.8) | 32.7 (28 – 38) | N/D | rs846910 and rs12086634 | No association with obesity and diabetes |
| Age: 36 (28 – 46) | ||||||
| Ethnicity: American Indian | ||||||
| Nair, 2004 [35] | n: 706 (SNP1), 839 (SNP5) | SNP1: 429 (60.8) | N/D | N/D | SNP1 (rs846910 and rs3334312) | SNP1 – OR = 1.64; P = 0.01 |
| SNP5: 510 (60.8) | SNP5 (N/D, rs12086634 and rs6752) | SNP5 – OR = 1.34; P = 0.02 | ||||
| For T2DM (+) vs. T2DM (−) | ||||||
| Age: N/D | ||||||
| Ethnicity: Pima Indian | ||||||
| Robitaille, 2004 [36] | n: 217 | N/D | 29.6 ± 4.3 | N/D | 4478 T > G, 4437–4438insA and 10733G > C | No association with BMI, WC, HDL-c, TG, FPG, fasting insulin, BP, HOMA-IR |
| Age: 42.8 ± 7.9 | ||||||
| Ethnicity: French-Canadian | ||||||
| Miyamoto, 2009 [33] | n: 3005 | N/D | 22.8 ± 2.7 | 431 (14.3) | rs860185, −658G > A, +1930insA, rs12086634, rs2236905, rs2298930, rs932335 and rs6752 | No association with MetS |
| Age:65.8 ± 10.3 | ||||||
| Ethnicity: Japanese | ||||||
| Ku, 2009 [32] | n: 1401 | 757 (54.0) | 24.1 ± 3.0 | N/D | rs45441700, rs846908, rs701950, +1932Ginsdel, xrs932335, rs13306422, rs6752 and +30249 T > C | No association with WHR, BMI, FPG, HbA1c, fasting insulin, and HOMA-IR |
| Age: 61.8 ± 7.2 | ||||||
| Ethnicity: Korean | ||||||
| Moon, 2011 [34] | n: 785 | 427 (54.4) | 23.3 ± 0.2 | N/D | rs12086634 and rs1000283 | No association with T2DM and MetS |
| Age: 62.2 ± 0.5 | ||||||
| Ethnicity: Korean | ||||||
| Dujic, 2012 [29] | n: 86 | N/D | 28.9 (25.7 – 31.5) | 43 (50.0) | rs846910 and rs45487298 | rs846910 related with ↓ HOMA-IR; P = 0.011a |
| Age: 47 (40 – 53) | rs45487298 related with ↓ HOMA-IR; P = 0.04b | |||||
| Ethnicity: Bosnian | ||||||
| Gandhi, 2013 [31] | n: 205 | 62 (30.2) | 25.7 ± 2.9 | 105 (51.2) | rs12086634 | Associated with MetS (OR = 6.64; P < 0.0001) |
| Age: 43 ± 11.5 | ||||||
| Ethnicity: South Indian | ||||||
| Turek, 2014 [37] | n: 215 | N/D | 26.5 ± 4.5 | N/D | rs846910 and rs12086634 | rs846910 not related with BMI and FPG |
| Age: N/D (22 – 72) | rs12086634 not related with FPG; P = 0.06 | |||||
| Ethnicity: Euro-Brazilian |
Data expressed as absolute and relative frequencies, median (interquartile range), or mean ± standard deviation as appropriate. N/D: not described; T2DM: type 2 diabetes mellitus; BMI: body mass index; MetS: metabolic syndrome; WC: waist circumference; HDL-c: HDL cholesterol; TG: triglycerides; FPG: fasting plasma glucose; BP: blood pressure; HOMA-IR: homeostatic model assessment of insulin resistance; HbA1c: glycated hemoglobin A1c; NPG: non-polymorphic group; PG: polymorphic group. ain MetS (+) group. bin control group.