Table 3.

Tier 1 overall positive outcome rates. Dose groups that achieve the required positive outcome rate to be considered promising as defined by our Tier 1 effectiveness evaluation plan are shaded in yellow

Group	Outcome	(Vehicle) 0 mg/kg/day	10 mg/kg/day	20 mg/kg/day	40 mg/kg/day	60 mg/kg/day
1‐h RNR	Pathology	4/20	0/10	1/10	2/10	0/10
	Mitochondria	10/20	6/10	4/10	5/10	4/10
	Total positive outcome rate	14/40 (35%)	6/20 (30%)	5/20 (25%)	7/20 (35%)	4/20 (20%)
6‐h RNR	Pathology	2/10	2/10	4/10	1/10	3/10
	Mitochondria	5/10	7/10	6/10	5/10	6/10
	Total positive outcome rate	7/20 (35%)	9/20 (45%)	10/20 (50%)	6/20 (30%)	9/20 (45%)
1‐h CCI	Pathology	4/20	1/10	4/10	2/10	6/10
	Mitochondria	9/20	6/10	4/10	6/10	5/10
	Total positive outcome rate	13/40 (33%)	7/20 (35%)	8/20 (40%)	8/20 (40%)	11/20 (55%)
6‐h CCI	Pathology	2/10	4/10	5/10	3/10	4/10
	Mitochondria	5/10	7/10	4/10	3/10	5/10
	Total positive outcome rate	6/20 (30%)	11/20 (55%)	9/20 (45%)	6/20 (30%)	9/20 (45%)

Abbreviations: RNR = rapid nonimpact rotation; CCI = controlled cortical impact.