Table 1.
Shift in EC50 (EC80) by microRNAs or antagomirs
| Cell line | miRNA | Drug | EC50 (nM) |
|---|---|---|---|
| Panc1 | ctrl | Gemcitabine | > 10,000 |
| miR-200 | Gemcitabine | 43 | |
| miR-203 | Gemcitabine | 19 | |
| MiaPaca | ctrl | Gemcitabine | 830 |
| miR-200 | Gemcitabine | 22 | |
| miR-203 | Gemcitabine | 23 |
| EC50/EC80 | |||
|---|---|---|---|
| hPaca 1 | ctrl | Gemcitabine | 10.8/98 |
| miR-200 | Gemcitabine | 8.7/28 | |
| miR-203 | Gemcitabine | 5.2/9.4 | |
| hPaca 2 | ctrl | Gemcitabine | 6.2/34 |
| a miR-200 | Gemcitabine | 8.2/88 | |
| a miR-203 | Gemcitabine | 7.6/85 | |
| MDA-MB231 | ctrl | Paclitaxel | 4.9/1050 |
| miR-200 | Paclitaxel | 6.1/24 | |
| miR-203 | Paclitaxel | 4.4/15 |