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Effects of combinations of mocetinostat or SAHA with chemotherapeutics
| Cell line | Moc plus | Gemzar (nM) | EC50 moc (μM) | CI | Effect |
|---|---|---|---|---|---|
| Panc1 | 0 | 2.4 | |||
| 25 | 0.71 | 0.29 | Synergy | ||
| 50 | 0.41 | 0.17 | Synergy | ||
| hPaca 1 | 0 | 0.68 | |||
| 2 | 0.19 | 0.47 | Synergy | ||
| 3 | 0.07 | 0.41 | Synergy | ||
| hPaca 2 | 0 | 2.2 | |||
| 2 | 2.4 | > 1 | No |
| Docetaxel (nM) | |||||
|---|---|---|---|---|---|
| DU145 DR | 0 | 0.62 | |||
| 30 | 0.05 | 0.21 | Synergy |
CI = combination index; < 1 = synergistic.
