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. 2015 Mar 27;19(6):1234–1244. doi: 10.1111/jcmm.12472

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effects of overexpressing Steap4 on high glucose or S100B-induced TGF-β bioactivity and TGF-β transcriptional activity. Cells were exposed to normal glucose (NG, open bars), high glucose (HG, closed bars) or S100B (1 μM, closed bars) for 24 hrs. Steap4 overexpression plasmid (2 μg) and TGF-β reporter plasmid (phTG5-luc and p3TP-lux, 200 ng) were co-transfected into cells. (A) Effects of overexpressing Steap4 on HG-induced-TGF-β bioactivity. (B) Effects of overexpressing Steap4 on HG-induced-TGF-β promoter activity. (C) Effects of overexpressing Steap4 on S100B (1 μM) induced-TGF-β bioactivity. (D) Effects of overexpressing Steap4 on S100B (1 μM) induced-TGF-β promoter activity. Data were expressed as the means ± SEM of three independent experiments. *: P < 0.05 versus lane 1. #: P < 0.05 versus lane 2.