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. 2015 Mar 27;19(6):1234–1244. doi: 10.1111/jcmm.12472

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Overexpressing Steap4 attenuated glomerular fibronectin expression in streptozotocin-diabetic mice. Streptozotin-diabetic (DM) mice were given weekly intravenous injection of the pCMV-SPORT6 empty plasmid (DM + vector) or the pCMV-SPORT6-Steap4 expression plasmid (DM + Steap4). Kidneys were removed on week 8, perfused and immersed in 4% paraformaldehyde and kidney slices were embedded in the paraffin block and cut into 3-μm sections for immunohistochemical study. Steap4 (A) and fibronectin (B) expression in a DM mouse was shown. Steap4 expressions in a control (C), DM + vector (D) and DM + Steap4 (E) mouse were shown. Fibronectin expressions in a control (F), DM + vector (G) and DM + Steap4 (H) mouse were shown.