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. 2015 Feb 16;19(6):1346–1356. doi: 10.1111/jcmm.12520

Figure 4.

Figure 4

PAR-1 inhibition in PAR-2 deficient mice does not attenuate collagen deposition and active-TGF-β production to a greater extent than single receptor targeting. Representative pictures (×100) of (A) Masson-trichrome and (B) collagen stained lung sections obtained 14 days after bleomycin instillation. (C) Quantification of collagen immunostaining in the different groups of mice (semi-quantitative image analysis). Hydroxyproline content (D) and TGF-β1 levels (E) in lung homogenates of the different groups of mice obtained 14 days after saline or bleomycin instillation. Mice not instilled with bleomycin are indicated as saline. Data are expressed as mean ± SEM (n = 8 per group). *P < 0.05, **P < 0.01.