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. 2015 Mar 19;19(6):1418–1425. doi: 10.1111/jcmm.12576

Figure 3.

Figure 3

MALAT1 induced regulation of cytokine induction occurs mostly through SAA. HUVECs, treated with 5 mM glucose (NG) or 25 mM glucose (HG), were transfected with siRNA for MALAT1 and scrambled siRNA (SCr) used as control. Apo-SAA, a recombinant peptide, was used to stimulate SAA pathways and bring about downstream effects. (A) IL-6 and (B) TNF-α MRNAs were measured at 24 hrs time-point in the presence and absence of MALAT1 silencing. [mRNA data are expressed as a ratio to 18sRNA and all data (mean ± S.E.) are normalized to controls, n = 3 or more per group, *: significantly different from control and @: significantly different from Apo SAA treated groups with MALATSi, SAA Si: SAA3 siRNA].