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MALAT1 expression is up-regulated in the kidneys of diabetic mice. Streptozotocin induced diabetic mice maintained in the hyperglycaemic state for 2 months showed increased mRNA expression of both (A) MALAT1 and (B) SAA 3. Such increases were associated with (C) TNF-α and (D) IL-6 mRNA up-regulation (data are expressed as mean ± S.E., expressed as a ratio to 18sRNA, normalized to controls, n = 4–5/group, *: P < 0.05).
