. Author manuscript; available in PMC: 2015 Jun 8.

Published in final edited form as: Can J Neurol Sci. 2013 Sep;40(5):652–656. doi: 10.1017/s0317167100014876

Table.

General characteristics of 19 adult patients with 22q11.2 deletion syndrome

Demographic and neuropsychiatric characteristics						Seizure related findings
							EEG findings			MRI findings
Case #	Sex	Age (y)	disability	SZ	neuropsych	Seizure type	IED	IS	BA	other	PMG	PNH	HIMAL
Patients with epilepsy
1	F	23	Borderline	✓	ADHD	GTCS and MS	3–4Hz G-PWS		N	✓			✓
2	M	58	Mild	O		2° GTCS		BT	S
3	M	36	Severe	✓	OCD	CPS and 2° GTCS	RT, LFC		S
4	F	19	Mild	✓	OCD	CPS and 2° GTCS		G	S			✓RFH	✓
5	M	34	Mild	✓		CPS and 2° GTCS		G	N			✓LFH	✓
6	F	43	Borderline	✓		CPS	BT	BT	N		✓	✓LFH
7	M	24	mild			CPS	BF		S
Patients without epilepsy
8	F	22	Mild		MD		LFC	BF	N	✓
9	F	40	Borderline	✓				BPQ	N	^*/WM
10	M	20	Borderline					BT	N	^**
11	M	19	Borderline	✓					N	✓			✓
12	M	30	Mild	✓					N	✓			✓
13	M	34	Mild	✓				G	N				✓
14	F	20	Mild		MD				N				✓
15	F	37	Borderline		MD, GAD				N
16	F	26	Borderline		MD				N				✓
17	M	21	Normal		ASD				N	✓			✓
18	M	37	Borderline	✓					S	✓
19	M	37	Borderline	✓	OCD				S

All patients with schizophrenia (SZ) or other psychotic illnesses were receiving antipsychotic medications. Patients with major depression and/or anxiety disorders were receiving antidepressant/antianxiety medications. All patients were either treated for documented hypocalcemia or received prophylactic vitamin D and calcium supplements for the elevated risk of hypocalcemia in 22q11DS.

hipocampal atrophy;

^**

focal scarring over right mid-temporal gyrus;

Inline graphic : psychosis not otherwise specified; 2° GTCS: secondarily generalized tonic-clonic seizures; ADHD: attention deficit hyperactivity disorder; ASD: autism spectrum disorder; BA: background activity; BF: bi-frontal; BPQ: both posterior quadrants; BT: bi-temporal; CPS: complex partial seizures; EEG: electroencephalogram; G: generalized; GAD: generalized anxiety disorder; G-PSW: generalized polyspike and waves; GTCS: generalized tonic-clonic seizures; HIMAL: hippocampal malrotation; IED: interictal epileptiform discharges; IS: intermittent slowing; LFC: left fronto-central; LFH: left frontal horn MD: major depression; MRI: magnetic resonance imaging; MS: myoclonic seizures; N: Normal; OCD: obsessive compulsive disorder; PMG: polymicrogyira; PNH: periventricular nodular heterotopia; RFH: right frontal horn; RT: right temporal; S: slow; SZ: schizophrenia, WM: white matter.