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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2015 May 11;25(14):2837–2843. doi: 10.1016/j.bmcl.2015.04.104

Figure 2. Synthesis of Compounds 1–6.

Figure 2

Reagents: (i) flumethasone-21-mesylate (Compounds 1 and 2), budesonide-21-mesylate (Compounds 3 and 4), beclomethasone-21-mesylate (Compounds 5 and 6); (ii) 2-iminothiolane-HCl (Traut’s Reagent); (iii) spermine.