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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Prog Biophys Mol Biol. 2015 Apr 1;118(0):21–33. doi: 10.1016/j.pbiomolbio.2015.03.002

Figure 1. Multigenerational and Transgenerational Phenotypes Following Drug Exposure.

Figure 1

Paternal or maternal exposure paradigms are used as a model for inheritance in rodents. F0 males or females exposed to drug prior to mating produce F1 offspring with multigenerational phenotypes and F2 offspring with transgenerational phenotypes (top). F0 females exposed to drug during pregnancy produce F1 and F2 offspring with multigenerational phenotypes and F3 offspring with transgenerational phenotypes (bottom).