Table 2.

Coronary artery disease: genetic loci with genome-wide significant association.

Clinical coronary artery disease
1p13 (SORT1) rs602633*,# p=1×10−25	3q22 (MRAS) rs9818870 p=3×10−9	6q26 (PLG) rs4252120£ p=5×10−10	10q23 (LIPA) rs2246833 p=9×10−6	17p11 (PEMT) rs12936587 p=1×10−9
1p32 (PPAP2B) rs17114036 p=6×10−12	4q31 (EDNRA) rs1878406 p=3×10−8	7p21 (HDAC9) rs2023938 p=5×10−8	10q24 (CYP17A1) rs12413409¤ p=6×10−8	17p13 (SMG6) rs2281727 p=8×10−9
1p32 (PCSK9) rs11206510* p=2×10−5	4q32 (GUCY1A3) rs7692387¤ p=3×10−11	7q22 (COG5) rs12539895 p=5×10−4	11q22 (PGFD) rs974819 p=4×10−11	17q21 (GIP) rs15563£ p=9×10−6
1q21 (IL6R) rs4845625 p=4×10−10	5q31 (SLC22A4) rs273909 p=1×10−9	7q32 (ZC3HC1) rs11556924¤,£ p=7×10−17	11q23 (APOA1) rs9326246*,§,# p=2×10−7	19p13 (LDLR) rs1122608* p=6×10−14
1q41 (MIA3) rs17464857 p=6×10−5	6p21 (ANKS1A) rs12205331# p=4×10−5	8p21 (LPL) rs264§,# p=3×10−9	12q24 (SH2B3) rs3184504¤,#,&,£ p=5×10−11	19q13 (APOE) rs2075650*,§,# p=6×10−11
2p11 (VAMP8) rs1561198 p=1×10−10	6p21 (KCNK5) rs10947789 p=1×10−8	8q24 (TRIB1) rs2954029*,§,# p=5×10−9	13q12 (FLT1) rs9319428 p=7×10−11	21q22 (KCNE2) rs9982601 p=8×10−17
2p21 (ABCG5) rs6544713* p=2×10−9	6p24 (ADTRP) rs6903956 p=5×10−12	9p21 (CDKN2A/CDKN2B) rs1333049 p=1×10−52	13q34 (COL4A1-COL4A2) rs4773144 p=1×10−11
2p24 (APOB) rs515135* p=3×10−10	6p24 (PHACTR1) rs9369640 p=8×10−22	9q34 (ABO) rs579459* p=3×10−8	14q32 (HHIPL1) rs2895811 p=4×10−10
2q22 (ZEB2) rs2252641 p=5×10−8	6q23 (TCF21) rs12190287 p=5×10−13	10p11 (KIAA1462) rs2505083 p=1×10−11	15q25 (ADAMTS7) rs7173743 p=7×10−13
2q33 (WDR12) rs6725887£ p=1×10−15	6q25 (LPA) rs3798220* p=5×10−5	10q11 (CXCL12) rs501120 p=2×10−9	15q26 (FURIN) rs17514846¤ p=9×10−11
Coronary artery calcium
Chromosome	Candidate gene	SNP	P-value
6p24	PHACTR1	rs9349379	p=3×10−11
9p21	CDKN2A/CDKN2B	rs1333049	p=8×10−19

Chromosomal loci, candidate genes, SNP and p-value at the 46 genetic loci associated with coronary artery disease in genome-wide association studies (p<5×10⁻⁸). Adapted from the CARDIoGRAMplusC4D study [18] (up to >60,000 cases and >130,000 controls) and a study of coronary artery calcium on computed tomography (nearly 16,000 subjects). [65] One locus (6p24 in ADTRP) was reported separately in a Chinese study. [48]

^*10 loci associated with higher LDL for CAD risk alleles,

^&1 locus with lower LDL,

^§4 loci with higher TG,

^#7 loci with lower HDL,

^¤5 loci with higher blood pressure.,

^£5 coding variants with r² > 0.9 to index SNP in 1000 Genomes CEU.