Table 3.

Ischemic stroke and carotid artery disease: genetic loci with genome-wide significant association.

Phenotype	Chromosome	Candidate gene	SNP	P-value	Study
Carotid artery disease
Common carotid IMT	8q24	ZHX2	rs11781551	2×10−11	[94]
Common carotid IMT	8p23	PINX1	rs6601530	2×10−8	[94]
Common carotid IMT	19q13	APOC1	rs445925	2×10−8	[94]
Carotid plaque	4q31**	EDNRA	rs1878406	7×10−12	[94]
Carotid plaque	7q22	PIK3CG	rs17398575	2×10−12	[94]
Ischemic stroke
Cardioembolic stroke	4q25*	PITX2	rs6843082	3×10−16	[86]
Cardioembolic stroke	16q22*	ZFHX3	rs879324	3×10−8	[86, 107]
Carotid-artery stroke	6p21	CDC5L/VEGFA	rs556621		[93]
Carotid-artery stroke	7p21**	HDAC9	rs2107595	2×10−12	[86, 88]
Carotid-artery stroke	9p21**	CDKN2A/CDKN2B	rs2383207	3×10−5	[86, 87]
Carotid-artery stroke	11q22	MMP12	rs660599	3×10−8	[150]
Ischemic stroke	12q24	SH2B3/ALDH2	rs10744777	7×10−11	[90]

P-values and references refer to the initial discovery study.

^*Also associated with atrial fibrillation.

^**Also associated with coronary artery disease.