Table 4.

Cardiac arrhythmia and cardiomyopathy: genetic loci with genome-wide significant association.

Phenotype	Chromosome	Candidate gene	SNP	P-value	Reference
Ventricular arrhythmia
Sudden cardiac death	2q24	TANC1*	rs4665058	2×10−10	[113]
Ventricular fibrillation	21q21	CXADR	rs2824292	3×10−10	[85]
Atrial arrhythmia
Atrial fibrillation	1q21	KCNN3	rs13376333	2×10−21	[109]
Atrial fibrillation	1q24	PRRX1	rs3903230	8×10−14	[110]
Atrial fibrillation	3p25	CAND2	rs4642101	1×10−8	[111]
Atrial fibrillation	4q25	PITX2	rs2200733	2×10−30	[106]
Atrial fibrillation	6q22	GJA1	rs13216675	2×10−8	[111]
Atrial fibrillation	7q31	CAV1	rs3807989	4×10−12	[110]
Atrial fibrillation	9q22	C9orf3	rs10821415	4×10−11	[110]
Atrial fibrillation	10q22	SYNPO2L	rs10824026	4×10−9	[110]
Atrial fibrillation	10q24	NEURL	rs12415501	7×10−16	[111]
Atrial fibrillation	12q24	TBX5	rs10507248	6×10−11	[111]
Atrial fibrillation	12q24	CUX2	rs6490029	4×10−9	[111]
Atrial fibrillation	14q23	SYNE2	rs1152591	6×10−13	[110]
Atrial fibrillation	15q24	HCN4	rs7164883	3×10−17	[110]
Atrial fibrillation	16q22	ZFHX3	rs2106261	2×10−15	[107, 108]
Sick sinus syndrome	14q11	MYH6	rs2231801	1×10−13	[122]
Cardiomyopathy
Dilated cardiomyopathy	1p36	HSPB7*	rs1739843	5×10−13	[100, 101]
Dilated cardiomyopathy	6p21	HCG22	rs9262636	5×10−9	[102]
Dilated cardiomyopathy	10q26	BAG3*	rs2234962	6×10−13	[100]
Hypertrophic cardiomyopathy	18q12	FHOD3*	rs2303510	2×10−9	[103]
Peripartum cardiomyopathy	12p11	PTHLH	rs258415	2×10−8	[99]

P-values and references refer to the initial discovery study.

^*coding variant with r² > 0.9 to index SNP in 1000 Genomes CEU.