Table 3.

Cox Proportional Hazards Model of the Bi-Directional Association of MD and T2DM

	Age 40 – 55		Age >55
	Model 1 HR (95% CI)	Model 2 HR (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)
MD predicting T2DM
MD (ref. Never)	1.49 (1.14 – 1.94)	1.32 (1.00 – 1.80)	1.04 (0.89 – 1.21)	1.00 (0.83 – 1.21)
T2DM predicting MD
T2DM (ref. Never)	1.40 (1.12 – 1.74)	1.33 (1.02 – 1.72)	1.05 (0.91 – 1.22)	1.02 (0.85 – 1.22)
N	16631	16631	20214	20214

HR: Hazard ratio from Cox proportional hazards model.

Model 1 adjusted for age and sex. Model 2 adjusted for age, sex, and genetic risk as indexed by co-twin status.