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. 2013 Mar 27;109(12):2866–2882. doi: 10.1152/jn.00021.2013

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Fig. 9. — Modulatory effects of GABA_B. A: GABA_B modulated peak IPSP amplitude. Left, responses of a P28 neuron at (threshold + 90) V stimulation in aCSF + APV + DNQX (black trace) to isolate the IPSP and in aCSF + APV + DNQX + CGP-52432 (gray trace) to block GABA_B receptors. Right, responses of the same neuron at varying stimulation amplitudes. Note the increase of IPSP amplitude after GABA_B blockade. B: GABA_B modulated IPSP temporal properties. Shown is a P17 neuron at (threshold + 50) V stimulation in aCSF + APV + DNQX (black trace) and in ACSF + APV + DNQX + CGP-52432 (gray trace). C: difference waveform of the two traces shown in B. The positive component of the difference waveform corresponds to the increased GABA_A IPSP peak amplitude when GABA_B receptors are blocked. The negative longer-lasting component of the difference waveform corresponds to the postsynaptic GABA_B IPSP that is eliminated with CGP-52432. D: GABA_B modulated recovery after repetitive stimulation. P16 neuron responses at 50 Hz in aCSF + APV + DNQX (black trace) and aCSF + APV + DNQX + CGP-52432 (gray trace) are shown. E: GABA_B response of a P17 neuron to a 50-Hz train isolated with aCSF + APV + DNQX + picrotoxin.