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. Author manuscript; available in PMC: 2016 Feb 20.
Published in final edited form as: Oncogene. 2014 Dec 8;34(34):4519–4530. doi: 10.1038/onc.2014.386

Figure 6. Relevance of changes in EZH2, β-catenin and WIF1 expression to humans.

Figure 6

Representative photomicrographs of paraffin embedded sections prepared from humans with adenocarcinoma and either without (A, left panel) or with (A, right panel; B, lower panel) invasive front. Sections were stained with antibodies for: EZH2, β-catenin and WIF1 (Original magnification = 200X; n = 2 independent experiments). A total of 18 de-identified adenoma/adenocarcinoma samples and the corresponding controls were analyzed for EZH2 and WIF1 staining. Significant inverse correlation between EZH2 and WIF1 labeling were recorded that paralleled staining pattern observed with mouse models of colon cancer.