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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2014 Dec 24;83:44–54. doi: 10.1016/j.yjmcc.2014.12.017

Figure 2. Mitochondrial damage and inflammasome activation.

Figure 2

Mitochondrial damage leads to increased ROS production and oxidative damage to mtDNA. Damaged mitochondria are ordinarily cleared via mitophagy mediated by PINK1/parkin/p62, but if mitophagy is impaired by overnutrition or advanced age, then mtDNA with 8-oxoG modifications may be released into cytosol, where it can interact with TLR9 and the NLRP3 inflammasome to trigger IL-1 beta synthesis and processing.