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. 2015 Jun 8;10(6):e0128442. doi: 10.1371/journal.pone.0128442

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© 2015 Yan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — One-sample t test results of (a) WM activation in the high-memory load (3-back > 2-back), RS connectivity of (b) DMN, (c) ECN, and (d) HPN in APOE-ε4 carriers and non-carriers. (a) APOE-ε4 carriers showed decreased activation across the whole brain regions. (b) Both groups displayed consistent DMN connectivity maps. (c) APOE-ε4 carriers displayed enhanced ECN connectivity in the left middle frontal gyrus, right insula, and bilateral thalamus (blue arrows). (d) APOE-ε4 carriers showed decreased HPN connectivity in the medial frontal gyrus and right insula (blue arrows). WM = working-memory; RS = resting-state; DMN = default mode network; ECN = executive control network; HPN = hippocampal network; L = left hemisphere; R = right hemisphere.