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. 2015 Jun 8;209(5):721–738. doi: 10.1083/jcb.201411104

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© 2015 Xie et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — Silencing of Nrf2 or Erbin rescues the phenotypes induced by Sag deletion. (A–C) Ad-C;K;S^fl/fl keratinocytes were infected with siRNA targeting either Nrf2 or Erbin, followed by IB (A and C), or ROS measurement by DCFHDA staining and photographed with a fluorescence microscope (B, left) and quantified with a flow cytometer (B, right; n = 2). (D–F) Autophagy was detected using the Cyto-ID autophagy detection kit (D), senescence using X-gal staining (E), and cell proliferation by ATPlite assay kit (F; n = 5). The data shown are from a single representative experiment out of three repeats. For the experiment shown, a total of 300 cells were counted in each group (D and E). Error bars indicate the SEM. LE, long exposure; SE, short exposure. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Bars, 20 µm.