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(A): Representative images confocal microscopy for total intracellular ROS production; (B & C): Western blotting analysis of NLRP3 and caspase-1 expression (P < 0.05); (D): ELISA of IL-1β secretion (P < 0.05). HG: high glucose; NG: normal glucose; NLRP3: nucleotide-binding oligomerization domain receptor 3; siNCLX: siRNA construct; ROS: reactive oxygen species. *P < 0.05.
