Table 4.
Enriched CNS Gene Sets, Duplications
| Ngene | p | Padj | OR (95% CI) | |
|---|---|---|---|---|
| Abnormal associative learning | 193 | 1.6×10−10 | 6.2×10−8 | 1.73 (1.46–2.08) |
| NMDAR network | 59 | 2.5×10−9 | 1.0×10−6 | 3.09 (2.09–4.67) |
| Abnormal long-term potentiation | 145 | 1.1×10−6 | 0.00044 | 1.65 (1.34–2.04) |
| Abnormal avoidance learning behavior | 56 | 1.6×10−6 | 0.00066 | 1.89 (1.45–2.47) |
| Abnormal cued conditioning behavior | 68 | 1.4×10−5 | 0.0055 | 2.02 (1.41–3) |
| GABAA | 15 | 5.4×10−5 | 0.022 | 2.8 (1.56–5.67) |
| Abnormal contextual conditioning behavior | 89 | 0.00011 | 0.045 | 1.68 (1.28–2.23) |
| Abnormal consumption behavior | 442 | 0.00050 | 0.20 | 1.27 (1.1–1.46) |
| Abnormal temporal memory | 108 | 0.00052 | 0.21 | 1.56 (1.2–2.04) |
| Thin cerebral cortex | 45 | 0.00060 | 0.24 | 1.94 (1.3–2.92) |
CNS gene sets with Puncorrected < 0.001 in the analysis of duplications are listed along with number of genes in each set, Ngene; uncorrected (p) and Bonferroni-corrected (Padj) p values for enrichment in case CNVs; and estimated odds ratios (OR). Note that while the NMDAR network was analyzed prior to other terms in this table, here it is corrected for the same number of tests as other terms for ease of comparison. See also Tables S1 and S3.