Table 2.
Genome-wide association studies in CHD patients.
| Platform(s) | Patients | Genetic Alteration | Impact | Reference |
|---|---|---|---|---|
| Illumina 660W-Quad | 798 TOF | 12q24 (PTPN11) 13q32 (GPC5, NRP1) |
risk allele for TOF risk allele for TOF |
[33] |
| SEQUENOM MALDI-TOF | 362 TOF | rs11066320 (PTPN11) | risk allele for TOF | [34] |
| NimbleGen sequence capture 365K array Genome Sequencer FLX Illumina Genome Analyzer |
26 TOF | deleterious SNPs in sixteen genes | imbalance of functional networks in TOF | [40] |
| Applied Biosystems Linkage Mapping Set (medium-density) |
43 families with LVOT | 2q23, 10q21, 16p12 16p12 10q11 2p15 |
risk loci for LVOT risk locus for AVS, CoA, HLHS risk locus for AVS, CoA risk locus for HLHS |
[42] |