Table 6.
Alteration of DNA methylation in CHD patients.
| Platform | Patients | Changes in Methylation | Impact | Reference |
|---|---|---|---|---|
| Illumina Infinium Human Methylation27 Bead Chip |
180 mothers with non- syndromic CHD pregnancy | 425 sites with differential methylation (e.g. EGFR, GATA4, WNT5S) |
risk for CHD pregnancy | [104] |
| Sequenom MassArray EpiTyper | 30 TOF | hypermethylation of NKX2.5 and HAND1 | potential relevance for TOF | [110] |
| Sequenom MassArray EpiTyper | 32 TOF | hypermethylation of NKX2.5 and HAND1,hypomethylation of TBX2 and LINE-1 | potential relevance for TOF increased risk for TOF |
[109] |
| Sequenom MassArray EpiTyper | 42 TOF | 17 genes hypermethylated, 9 genes hypomethylated |
representative methylator phenotype phenotype during TOF development |
[111] |
| MethyLight | 180 mothers with non-syndromic CHD pregnancy | global hypomethylation (LINE-1) | risk for CHD pregnancy | [113] |