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. 2015 Jun 1;2015:469459. doi: 10.1155/2015/469459

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Copyright © 2015 Manuel Scimeca et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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BMP-2 and satellite stem cells in muscle regenerations. ((a)-(b)) Hematoxylin and eosin sections of muscle biopsies showed a significant increase of fat tissue in OA (a) as compared to OP patients (b) (40x). (c) Image showed numerous BMP-2 positive fibers (40x). Often, in OP patients we did not observed BMP-2 expression (40x) (d). The Immunohistochemistry for myostatin was negative in OA muscle tissue (40x) (e). Muscle biopsies of OP group showed high/moderate expression of myostatin (40x) (f) inversely related to BMP-2 immunostain. Groups of satellite cells CD44 positive were focally dispersed in the tissue (200x) of OA patients (g) higher than that observed in OP patients (200x) (h).