Figure 5. PMK proteins are stimulated by osmotic stresses in mammalian cells.
HEK-293 cells were transfected as indicated and incubated in medium containing either 0.5 M sorbitol or 0.7 M NaCl for fifteen minutes prior to harvest. Proteins were immunoprecipitated with a monoclonal anti-HA antibody and incubated with ATF-2 in kinase assays. Reactions were analyzed by SDS/PAGE and autoradiography.